--- title: Research and studies description: The latest research results and innovations in zirconia ceramics and dental implants. Learn more about the leading role of Z-SYSTEMS in ceramic implant research. --- - [Downloads](https://www.zsystems.com/download) - [eIFU](https://ifu.zsystems.com/) - [Research & studies](https://www.zsystems.com/research-and-studies) - [DE](https://www.zsystems.com/de/) - [FR](https://www.zsystems.com/fr/) - [JP](https://www.zsystems.com/ja/) [Skip to content](https://www.zsystems.com/research-and-studies#main-content) [![z-systems-logo-1](https://www.zsystems.com/hubfs/00_Brand/z-systems-logo-1.svg "z-systems-logo-1")](https://www.zsystems.com/) - [Dentists Show submenu for Dentists](https://www.zsystems.com/dentists) - [Implant Systems Show submenu for Implant Systems](https://zsystems.com/dentists#products) - [Z5-BL](https://zsystems.com/dentists#z5-bl) - [Z5-TL](https://zsystems.com/dentists#z5-tl) - [Z5m](https://zsystems.com/dentists#z5m) - [Certification Standards](https://zsystems.com/dentists#certificationstandards) - [Onboarding](https://zsystems.com/dentists#onboarding) - [Marketing Support](https://zsystems.com/dentists#toolkit) - [Continuing Education & Events](https://www.zsystems.com/events) - [FAQ](https://zsystems.com/dentists#faq) - [Warranty](https://www.zsystems.com/warranty) - [Dental Technicians](https://www.zsystems.com/dentaltechnicians) - [Patients Show submenu for Patients](https://www.zsystems.com/patients) - [Advantages ceramic implants](https://zsystems.com/patients#advantages) - [Implant treatment](https://zsystems.com/patients#implant-treatment) - [FAQ](https://zsystems.com/patients#faq) - [Dentist search](https://zsystems.com/patients#dentist-search) - [About us Show submenu for About us](https://www.zsystems.com/about-us) - [History](https://zsystems.com/about-us#history) - [Our values](https://zsystems.com/about-us#values) - [Certification standards](https://zsystems.com/about-us#certificates) - [Contact](https://zsystems.com/about-us#contact) - [Dentists Show submenu for Dentists](https://www.zsystems.com/dentists) - [Implant Systems Show submenu for Implant Systems](https://zsystems.com/dentists#products) - [Z5-BL](https://zsystems.com/dentists#z5-bl) - [Z5-TL](https://zsystems.com/dentists#z5-tl) - [Z5m](https://zsystems.com/dentists#z5m) - [Certification Standards](https://zsystems.com/dentists#certificationstandards) - [Onboarding](https://zsystems.com/dentists#onboarding) - [Marketing Support](https://zsystems.com/dentists#toolkit) - [Continuing Education & Events](https://www.zsystems.com/events) - [FAQ](https://zsystems.com/dentists#faq) - [Warranty](https://www.zsystems.com/warranty) - [Dental Technicians](https://www.zsystems.com/dentaltechnicians) - [Patients Show submenu for Patients](https://www.zsystems.com/patients) - [Advantages ceramic implants](https://zsystems.com/patients#advantages) - [Implant treatment](https://zsystems.com/patients#implant-treatment) - [FAQ](https://zsystems.com/patients#faq) - [Dentist search](https://zsystems.com/patients#dentist-search) - [About us Show submenu for About us](https://www.zsystems.com/about-us) - [History](https://zsystems.com/about-us#history) - [Our values](https://zsystems.com/about-us#values) - [Certification standards](https://zsystems.com/about-us#certificates) - [Contact](https://zsystems.com/about-us#contact) [Downloads](https://www.zsystems.com/download)[Research & Studies](https://www.zsystems.com/research-and-studies)[DE](https://www.zsystems.com/de/)[FR](https://www.zsystems.com/fr/)[JP](https://www.zsystems.com/ja/) [Contact](https://www.zsystems.com/contact) Get started Load more # Research & studies The latest findings and advances in dental implant research: The latest studies and innovations on zirconium dioxide ceramics and dental implants. #### First clinical results of dental screw implants made of zirconium oxide [Mellinghoff J. Z Zahnärztl Impl 2006; 22(4): 288 (DE)](https://www.zsystems.com/hubfs/Erste%20klinische%20Ergebnisse%20zu%20dentalen%202006.pdf) #### Zirconium dioxide implants – Practical experience: What are the aesthetic benefits of ceramic implants? [Mellinghoff J. Implantologie 2014; 22(1): 51–60 (DE)](https://www.zsystems.com/hubfs/Zirkoniumdioxidimplantate%202014-1.pdf) #### Role of immune Dysregulation in peri-implantitis [Huang M., Wang C., Li P., Lu H., Li A., Xu S., Frontiers in Immunology 10.3389 1-17 (EN)](https://www.zsystems.com/hubfs/Role%20of%20immune%20dysregulation%20in%20peri-implantitis%202024.pdf) #### Clinical and radiographic outcomes of zirconia dental implants [Roehling S., Gahlert M., Bacevic M., Woelfler H., Laleman I. Clinical Oral Implants Res. 2023; 34(Suppl. 26): 112-124 (EN)](https://www.zsystems.com/hubfs/Clinical%20and%20radiographic%20outcomes%20of%20zirconia%20dental%20implants%202023.pdf) #### Survival and success of zirconia compared with titanium implants [Padhye N., Calcloarl E., Zuercher A., Tagliaferri S., Donos N., Clinical Oral Investigations 2023; (27) 6279-6290 (EN)](https://www.zsystems.com/hubfs/Survival%20and%20success%20of%20zirconia%20compared%20with%20titanium%20implants%202024.pdf) #### Two-piece zirconia implants with two various platforms: RCCT’s preliminary results [Oblak Č., Zarkovic Gjurin S., Hrovat P., Kobe T., Gašperšič R. CED-IADR, Oral Health Research Congress 2023, Abstract book, Nr. 0168, p. 91 (EN)](https://www.zsystems.com/hubfs/Two-Piece%20Zirconia%20Implants%20With%20Two%20Various%20Platforms_%20RCCTs%20Preliminary%20Results%20IADR%20Abstract%20Archives%20(1).pdf) #### One-piece ceramic implants: A longitudinal study over a two-year observation period [Mellinghoff J., Cacaci C., Detsch F. Implantologie 2015; 23(1): 89–100 (DE)](https://www.zsystems.com/hubfs/Einteilige%20Keramikimplantate%202014.pdf) #### Clinical Outcomes of Zirconia implants: a systematic review and meta-Analysis [Mohsen P., Soufi A., Chrcanovic B.R., Clinical Oral Investigations 2024; 1-12 (EN)](https://www.zsystems.com/hubfs/Clinical%20outcomes%20of%20zirconia%20implants%20a%20systematic%20review%202024.pdf) #### Two-piece zirconia implants in the posterior mandible and maxilla: A cohort study with a follow-up period of 9 years [Brunello G., Rauch N., Becker K., Hakimi A.R., Schwarz F., Becker J. Clin Oral Implants Res. 2022, 33(12), 1233 –1244 (EN)](https://www.zsystems.com/hubfs/Clinical%20Oral%20Implants%20Res%20-%202022%20-%20Brunello%20-%20Two%E2%80%90piece%20zirconia%20implants%20in%20the%20posterior%20mandible%20and%20maxilla%20%20A%20cohort%20(1).pdf) #### Quality assessment of five randomly chosen ceramic oral implant systems: Cleanliness, surface topography, and clinical documentation [Duddeck D.U., Albrektsson T., Wennerberg A., Larsson C., Mouhyi J., Beuer F. Int J Oral Maxillofac Implants 2021, 36(5), 863–874 (EN)](https://www.zsystems.com/hubfs/Quality%20Assessment%202020.pdf) #### Titanium particles in peri-implantitis: distribution, pathogenesis and prospects [Chen L., Tong Z., Luo H., Qu Y., Gu X., Si M., International Journal of Oral Science (2023); 1-13 (EN)](https://www.zsystems.com/hubfs/Titanium%20particles%20in%20peri-implantitis%202023.pdf) #### Quality of the peri-implant soft tissue attachment of zirconia implants (-abutments): Comparison of the results of a literature review with the experiences of dental practitioners [Mellinghoff J. Zahnärztl Impl 2010; 26(1): 62 (DE)](https://www.zsystems.com/hubfs/Qualit%C3%A4t%20des%20periimplant%C3%A4ren%20Weich%202010.pdf) #### Fracture resistance of a bone-level two-piece zirconia oral implant system - the influence of artificial loading and hydrothermal aging [Kohal R., Riesterer E., Vach K., Patzelt S., Ivekovic A., Einfalt L., Kocjan A., Hillebrecht A., J. Funct. Biomater 2024; 15(122) 1-16 (EN)](https://www.zsystems.com/hubfs/Fracture%20Resistance%20of%20a%20Bone-Level%202024.pdf) #### Influence of multiple used implant drills on their cutting performance and fracture resistance [Alevizakos V., Mosch R., von See C. Materials 2023, 16(15), 5271 (EN)](https://www.zsystems.com/hubfs/materials-16-05271%20(1).pdf) #### Ligature-induced peri-implant bone loss around loaded zirconia and titanium implants [Roehling St., Gahlert M., Janner S., Meng B., Woelfler H., Cochran D.L. Int J Oral Maxillofac Implants. 2019, 34(2), 357–36 (EN)](https://www.zsystems.com/hubfs/Ligature%20induced%202018.pdf) #### Immune dysregulation and macrophage polarization in peri-implantitis [Li Y., Li X., Guo D., Meng L., Feng X., Zhang Y., Pan S., Frontiers in Bioengineering and Biotechnology 2024; 10(3389) 1-14 (EN)](https://www.zsystems.com/hubfs/Immune%20dysregulation%20and%20macrophage%20polarization%20in%20peri-implantitis%202024.pdf) #### Is there a better biomaterial for dental implants than titanium? – A review and meta-study analysis [Haugen H.J., Chen H. Funct Biomater. 2022, 13(2), 46 (EN)](https://www.zsystems.com/hubfs/jfb-13-00046-v2%20(1).pdf) #### The systemic and local interactions related to titanium implant corrosion and hypersensitivity reactions: a narrative review of the literature [Swalsky A., Noumbissi S., Wiedemann T., International Journal of Implant Dentistry (2024) 1-10 (EN)](https://www.zsystems.com/hubfs/The%20systemic%20and%20local%20interactions%202024.pdf) #### Osseointegration of zirconia implants with different surface characteristics: an evaluation in rabbits [Hoffmann O., Angelov N., Zafiropoulos GG., Andreana S. Int J Oral Maxillofac Implants 2012; 27(2): 352–358 (EN)](https://www.zsystems.com/hubfs/Osseointegration%20of%20Zirconia%20implant%202012.pdf) #### Stability assessment of 85 standblasted and laser-etched surface zirconia implant using the periotest method over 4 months of bone integration time [Noumbissi S., Piconi C. Key Engineering Materials 2016, Vol. 720; 65–68 (EN)](https://www.zsystems.com/hubfs/Stability%20Assessment%20of%2085%20Sandblasted%20and%20Laser-Etched%20Surface%20Zirconia%20Implant%202016.pdf) #### Titanium allergy caused by dental implants: A systematic literature review and case report [Poli P.P., de Miranda F.V., Polo T.O.B., Santiago Júnior J.F., Lima Neto T.J., Rios B.R., Assunção W.G., Ervolino E., Maiorana C., Faverani., L.P. Materials 2021, 14(18), 5239 (EN)](https://www.zsystems.com/hubfs/Titanium%20Allergy%20Caused%20by%20Dental%20Implants_%20A%20Systematic%20Literature%20Review%20and%20Case%20Report.pdf) #### Histologic osseointegration level comparing titanium and zirconia dental implants: Meta-analysis of preclinical studies [da Silva Remísio M.J., Borges T., Castro F., Alexandre Gehrke S., Hasse Fernandes J.C., Vicentis de Oliveira Fernandes G. Int J Oral Maxillofac Implants 2023, 38(4), 667–680 (EN)](https://www.zsystems.com/hubfs/Histologic%20Osseointegration%20Level%20Comparing%20Titanium%20and%202022.pdf) #### One-piece versus two-piece ceramic dental implants [Bollen C., Hakobayan G., Jörgens M., British Dental Journal 2024; (236) 383-387 (EN)](https://www.zsystems.com/hubfs/One-piece%20versus%20two-piece%20ceramic%20dental%20implants%202024.pdf) #### Radioactive potential of zirconium-dioxide used for dental applications [Bavbek A., Özcan M., Eskitascioglu G., J. Appl. Biomater Funct Mater 2014; 12(1): 35-40](https://www.zsystems.com/hubfs/Radioactive%20potential%20of%20zirconium-dioxide%20used%20for%20dental%202014%20(1).pdf) #### Two-year outcomes of tissue-level and bone-level two-piece zirconia implants: a case series [Žarković Gjurin S., Povšič K., Kobe T., Žužek B., Gašperšič R., Oblak Č. Oral. 2026; 6(1):1 (EN)](https://www.zsystems.com/hubfs/Two-Year%20Outcomes%20of%20Tissue-Level%20and%20Bone-Level%20Two-Piece%20Zirconia%20Implants.pdf) #### Multivariate analysis of the survival rates and risk factors of one-piece zirconia implants supporting single crowns or fixed dental prostheses: a retrospective cohort study with follow-up periods of up to 8 years [Cortés-Bretón Brinkmann J., Bazal-Bonelli S., Suárez MJ., Meniz-García C., Madrigal Martìnez-Pereda C., López-Quiles J. Dentistry Journal. 2026; 14(5):282 (EN)](https://www.zsystems.com/hubfs/Multivariate%20Analysis%20of%20the%20Survival%20Rates%20and%20Risk%20Factors%20of%20One-Piece%20Zirconia%20Implants%20Supporting%20Single%20Crowns%20or%20Fixed%20Dental%20Prostheses.pdf) #### Long-term clinical and radiographic outcomes of ceramic dental implants: An 11-year retrospective cohort study Monzavi M., Masnavi M., Zraiqat A., Manesh A. J Esthet Restor Dent. 2026 (EN) ## Z-Systems Online Magazin #### [![Webinar Ceramic Implantology in Contemporary Practice](https://www.zsystems.com/hubfs/Webinar%20Dr%20Monzavi%20%26%20Dr%20al%20Manesh-1.png) 24.09.2026 12 min read 25.09.2026 Webinar Ceramic Implantology in Contemporary Practice Detail](https://www.zsystems.com/online-magazin/webinar-ceramic-implantology-in-contemporary-practice) #### [![10ème SYMPOSIUM SSO-Vaud](https://www.zsystems.com/hubfs/Blog%20SSO%20Vaud%202026%20Z-systems-1.jpg) 28.08.2026 2 min read 2025-11-26 10ème SYMPOSIUM SSO-Vaud Detail](https://www.zsystems.com/online-magazin/10ème-symposium-sso-vaud) #### [![Osnabrück Vortrag Kian Dilmaghani](https://www.zsystems.com/hubfs/Osnabr%C3%BCck%20Kongress%202026-1.jpg) 27.08.2026 2 min read 2025-09-25 Osnabrück Vortrag Kian Dilmaghani Detail](https://www.zsystems.com/online-magazin/osnabrück-vortrag-kian-dilmaghani) #### [![EAO Vortrag Prof. Dr. Dr. h.c., PhD Mutlu Ozcan](https://www.zsystems.com/hubfs/EAO%20Vortrag%20Mutlu%20Ozcan-1.jpg) 26.08.2026 2 min read 2025-09-25 EAO Vortrag Prof. Dr. Dr. h.c., PhD Mutlu Ozcan Detail](https://www.zsystems.com/online-magazin/eao-vortrag-prof.-dr.-dr.-h.c.-phd-mutlu-ozcan) #### [![Training Center L’implant en Zircone: Une alternative au titane](https://www.zsystems.com/hubfs/Training%20Center-3.jpg) 25.08.2026 4 min read 04.09.2026 Training Center L’implant en Zircone: Une alternative au titane Detail](https://www.zsystems.com/online-magazin/fr/online-magazin/training-center-limplant-en-zircone-une-alternative-au-titane) #### [![27e Congrès de la SDS](https://www.zsystems.com/hubfs/Featured.png) 18.08.2026 3 min read 2025-11-26 27e Congrès de la SDS Detail](https://www.zsystems.com/online-magazin/27e-congrès-de-la-sds) #### [![Webinar with Dr Emilio Mateo](https://www.zsystems.com/hubfs/Dr%20Emilo%20Webinar-1.jpg) 29.06.2026 7 min read 23.07.2026 Webinar: Natural Integration into the Esthetic Zone Detail](https://www.zsystems.com/online-magazin/webinar-natural-integration-into-the-esthetic-zone) #### [![Sam Talpis Webinar Z-Systems Ceramic implants, Zirkonia implants](https://www.zsystems.com/hubfs/Webinar%20Sam%20Talpis%20New%202.jpg) 17.04.2026 8 min read 21.04.2026 Webinar: Zirconia Implants: Where do they fit in modern clinical practice? 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